Table 2.

Up- and down-regulated gene sets in the normal prostate tissue of 16 men with low-risk prostate cancer who engaged in vigorous physical activity ≥3 h/wk compared to 55 men who engaged in <3 h/wk vigorous activity. Gene sets with a false discovery rate (FDR) <0.20 were considered significant.

Gene set name	Source	p-value	FDR
Up-regulated
G1 Pathway	BIOCARTA	>0.001	0.0
Formation of Fibrin Clot Clotting Cascade	REACTOME	>0.001	0.0
Inactivation of APC via Direct Inhibition of the APcomplex	REACTOME	>0.001	0.0
Cell Cycle	KEGG	0.001	0.10
TOB1 Pathway	BIOCARTA	0.001	0.10
G2 M Checkpoints	REACTOME	0.001	0.10
Phosphorylation of the APC	REACTOME	0.001	0.10
APCDC20 Mediated Degradation of Cyclin B	REACTOME	0.002	0.13
Chylomicron Mediated Lipid Transport	REACTOME	0.002	0.13
E2F Transcriptional Targets at G1 S	REACTOME	0.002	0.13
GA12 Pathway	STKE	0.002	0.13
E2F Mediated Regulation of DNA Replication	REACTOME	0.003	0.15
Homologous Recombination Repair	REACTOME	0.003	0.15
Cysteine And Methionine Metabolism	KEGG	0.004	0.15
Activation of ATR In Response to Replication Stress	REACTOME	0.004	0.15
Complement and Coagulation Cascades	KEGG	0.005	0.15
NKT Pathway	BIOCARTA	0.005	0.15
Cell Cycle Mitotic	REACTOME	0.005	0.15
Cyclin A1 Associated Events During G2 M Transition	REACTOME	0.005	0.15
Double Strand Break Repair	REACTOME	0.005	0.15
Fanconi Anemia Pathway	REACTOME	0.005	0.15
Lipoprotein Metabolism	REACTOME	0.005	0.15
Platelet Activation	REACTOME	0.005	0.15
NO2-IL12 Pathway	BIOCARTA	0.006	0.17
Formation of Platelet Plug	REACTOME	0.006	0.17
Down-regulated
SEMA4D in Semaphorin Signaling	REACTOME	>0.001	0.0
SEMA4D Induced Cell Migration and Growth Cone Collapse	REACTOME	>0.001	0.0