Table 3.
Up- and down-regulated gene sets in the normal prostate tissue of 35 men who met the US Physical Activity Guidelines for Older Adults1 compared to 46 men who did not meet the guidelines. Gene sets with a false discovery rate (FDR) <0.20 were considered significant.
| Gene set name | Source | p-value | FDR |
|---|---|---|---|
| Up-regulated | |||
| EGFR/ErbB Signaling Pathway | KEGG | >0.001 | 0.00 |
| Insulin Receptor Pathway in Cardiac Myocytes | SIG | >0.001 | 0.00 |
| Phosphoinositide 3 Kinase Pathway | ST | >0.001 | 0.00 |
| Wnt Ca2 Cyclic GMP Pathway | ST | 0.001 | 0.18 |
1
The US Physical Activity Guidelines for Older Adults are a minimum of 150 min/wk of moderate-intensity, or 75 min/wk of vigorous-intensity aerobic physical activity, or an equivalent combination of moderate- and vigorous-intensity aerobic activity.