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. Author manuscript; available in PMC: 2014 Oct 15.
Published in final edited form as: Cancer Res. 2014 Mar 31;74(8):2246–2257. doi: 10.1158/0008-5472.CAN-13-2131

Figure 6.

Figure 6

HOIP-depletion sensitizes a range of cancer cell lines to cisplatin-induced apoptotic cell death. HCT116 (A), HeLa (B), PC3 (C), ZR.75.1 (D), MDA-MB-231 (E) or PEA1 (F) cells were transfected with mock siRNA (siCON) or siRNA targeting HOIP (siHOIP) and treated with 5 μM cisplatin for the indicated time before cell lysates were analyzed by immunoblotting with the antibodies indicated (upper panels). Cell viability of siCON- or siHOIP-transfected cells in response to the indicated concentration range of cisplatin was measured by MTS cell proliferation assays (lower panels). Data shown are represented as mean ± SEM from three independent experiments.