Table 3. SNPs associated with ILC (P<5×10−8) or LCIS (P<0.05) in a pooled lobular analysis (GLACIER and BCAC).
| MAF | ILC vs Controls* | LCIS vs Controls** | P-het | |||||
| Cytoband | Gene | RS number | Controls | OR (95% CI) | P | OR (95% CI) | P | ILC vs LCIS |
| 10q26.13 | FGFR2 | rs2981579 | 0.40 | 1.38 (1.32, 1.44) | 5.1×10−52 | 1.19 (1.03, 1.37) | 0.019 | 0.04 |
| 16q12.1 | TOX3 | rs3803662 | 0.26 | 1.33 (1.27, 1.39) | 1.1×10−35 | 1.35 (1.16, 1.57) | 1.2×10−4 | 0.99 |
| 1p11.2 | rs11249433 | 0.40 | 1.25 (1.20, 1.30) | 2.7×10−25 | 1.15 (1.00, 1.33) | 0.050 | 0.94 | |
| 11q13.3 | rs554219 | 0.12 | 1.33 (1.26, 1.41) | 1.6×10−22 | 1.31 (1.08, 1.60) | 0.007 | 0.80 | |
| 9q31.2 | rs865686 | 0.38 | 0.83 (0.79, 0.86) | 1.0×10−17 | 0.72 (0.61, 0.84) | 2.2×10−5 | 0.12 | |
| 2q35 | rs13387042 | 0.49 | 0.84 (0.80, 0.87) | 5.7×10−17 | 0.90 (0.78, 1.04) | 0.145 | 0.21 | |
| 11q13.3 | rs75915166 | 0.06 | 1.40 (1.29, 1.51 | 1.2×10−16 | 1.55 (1.20, 2.01) | 7.8×10−4 | 0.54 | |
| 11q13.3 | rs614367 | 0.14 | 1.24 (1.18, 1.31) | 7.2×10−15 | 1.32 (1.10, 1.58) | 0.003 | 0.46 | |
| 10q21.2 | ZNF365 | rs10995190 | 0.16 | 0.80 (0.75, 0.85) | 1.7×10−13 | 0.69 (0.55, 0.87) | 0.002 | 0.10 |
| 5q11.2 | MAP3K1 | rs889312 | 0.28 | 1.18 (1.13, 1.23) | 9.1×10−13 | 1.05 (0.89, 1.22) | 0.576 | 0.03 |
| 10q22.3 | ZMIZ1 | rs704010 | 0.38 | 1.14 (1.10, 1.19) | 3.7×10−10 | 1.15 (0.99, 1.33) | 0.063 | 0.49 |
| 10p12.31 | MLLT10 | rs1243182 | 0.32 | 1.14 (1.09, 1.19) | 6.1×10−9 | 1.29 (1.11, 1.49) | 7.8×10−4 | 0.49 |
| 4q34.1 | ADAM29 | rs6828523 | 0.12 | 0.82 (0.77, 0.88) | 1.6×10−8 | 0.96 (0.77, 1.21) | 0.751 | 0.21 |
| 8q24.21 | rs13281615 | 0.41 | 1.13 (1.08, 1.18) | 2.1×10−8 | 1.13 (0.97, 1.30) | 0.116 | 0.86 | |
| 2q35 | DIRC3 | rs16857609 | 0.26 | 1.10 (1.05, 1.15) | 3.5×10−5 | 1.25 (1.07, 1.46) | 0.006 | 0.625 |
| 2q14.2 | rs4849887 | 0.10 | 0.91 (0.84, 0.97) | 0.007 | 0.71 (0.54, 0.93) | 0.012 | 0.11 | |
| 6q14.1 | rs17529111 | 0.22 | 1.06 (1.01, 1.11) | 0.020 | 1.25 (1.06, 1.48) | 0.009 | 0.04 | |
| 2p24.1 | rs12710696 | 0.36 | 1.05 (1.00, 1.09) | 0.037 | 1.17 (1.01, 1.35 | 0.034 | 0.10 | |
| 5p15.33 | TERT,hTERT | rs7726159 | 0.34 | 1.03 (0.99, 1.07) | 0.195 | 1.22 (1.05, 1.42) | 0.008 | 0.254 |
| 1q32.1 | LGR6 | rs6678914 | 0.41 | 1.02 (0.98, 1.06 | 0.415 | 0.77 (0.67, 0.90) | 8.0×10−4 | 0.0007 |
| 8q21.11 | rs6472903 | 0.18 | 0.98 (0.93, 1.03) | 0.459 | 0.81 (0.66, 0.99) | 0.036 | 0.11 | |
| 5p15.33 | TERT | rs10069690 | 0.26 | 1.01 (0.97, 1.06) | 0.615 | 1.18 (1.01, 1.38) | 0.040 | 0.19 |
*5622 cases, 34272 controls.
**401 cases, 24045 controls.