Table 4. SNPs showing differential lobular and ductal associations with breast cancer risk in BCAC subjects (ER+ tumours only).
IDC vs Controls* | ILC vs Controls** | P-het | ||||||
Cytoband | Genes | RS number | MAF | OR (95% CI) | P | OR (95% CI) | P | Ductal vs Lobular |
1p11.2 | rs11249433 | 0.400 | 1.09 (1.06, 1.13) | 2.3×10−9 | 1.28 (1.22, 1.35) | 7.1×10−20 | 2.7×10−8 | |
5p12 | rs10941679 | 0.254 | 1.17 (1.13, 1.21) | 4.0×10−21 | 1.03 (0.97, 1.10) | 0.318 | 1.5×10−4 | |
10q26.13 | FGFR2 | rs2981579 | 0.404 | 1.31 (1.27, 1.35) | 1.2×10−71 | 1.42 (1.35, 1.50) | 3.4×10−38 | 5.3×10−3 |
14q24.1 | RAD51L1 | rs2588809 | 0.158 | 1.12 (1.08, 1.17) | 8.7×10−9 | 0.99 (0.92, 1.07) | 0.870 | 0.001 |
10q21.2 | ZNF365 | rs10995190 | 0.158 | 0.87 (0.84, 0.91) | 4.1×10−11 | 0.76 (0.71, 0.83) | 1.2×10−11 | 0.002 |
8q21.11 | rs6472903 | 0.178 | 0.89 (0.85, 0.92) | 2.9×10−9 | 1.00 (0.93, 1.07) | 0.895 | 0.004 | |
2q31.1 | CDCA7 | rs1550623 | 0.156 | 0.93 (0.89, 0.96) | 2.1×10−4 | 1.01 (0.94, 1.08) | 0.839 | 0.031 |
*15023 cases, 29273 controls.
**3201 cases, 29273 controls.