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. 2014 Apr 17;8(4):e2796. doi: 10.1371/journal.pntd.0002796

Figure 1. Protein domains and immunologically-relevant regions of pvmsp-1 42 kDa region and pvcsp.

Figure 1

For both genes, numbers indicate coordinates according to the Sal1 reference genes. Sequences for pvmsp-1 (PVX_099980) and pvcsp (PVX_119355) were accessed August 14, 2012 from PlasmoDB.org. (A) The pvmsp-1 42 kDa region is composed of two primary subunits – a 33 kDa and a 19 kDa subunit. Other sub-regions, including the 20 kDa and 14 kDa HARBs have been previously defined and studied. Here, we define the region between the HARBs as the “intervening region.” (B) The pvcsp gene is composed of three regions – an N-terminal non-repeat region, a central repeat region, and a C-terminal non-repeat region. The central repeat region consists of two major nonapeptide repeat types, termed VK210 and VK247. Approximate locations of pvcsp regions I and II are noted with horizontal lines in the N- and C-terminal non-repeat regions, respectively.