Table 2. McDonald-Kreitman test for selection in pvmsp-1.
McDonald-Kreitman Comparisons | ||||
42 kDa region | 42 kDa intervening region | |||
Synonymous | Non-synonymous | Synonymous | Non-synonymous | |
Fixed | 96 | 93 | 32 | 28 |
Polymorphic | 34 | 39 | 10 | 31 |
p = 0.681 | p = 0.00427 |
Evidence for long-term selective pressure on the pvmsp-1 42 kDa region and the 42 kDa intervening region was assessed with the McDonald-Kreitman test, using P. knowlesi msp1 as the outgroup comparator. A Fisher's exact test (two tailed) was used to determine significance.