Table 1. The changes of significant mutations between treatment-naïve and experienced patients.
| Mutationsa , b | Treatment-naïve patients | Treatment-experienced patients | P value c | ||||
| Frequency (n) | Ka/Ks | LOD | Frequency (n) | Ka/Ks | LOD | ||
| W88C | 0.00% (0) | - | - | 2.20% (8) | 8.00 | 7.74 | <0.001 |
| A98G | 0.00% (0) | - | - | 1.93% (7) | 26.82 | 6.38 | <0.001 |
| K101Q | 0.00% (0) | - | - | 1.65% (6) | 4.38 | 2.64 | 0.001 |
| K103N | 0.95% (6) | 1.85 | 2.23 | 18.73% (68) | 32.29 | 64.51 | <0.001 |
| I132L | 0.00% (0) | - | - | 1.65% (6) | 6.00 | 6.02 | 0.001 |
| R135L | 0.32% (2) | 0.67 | >2.00 | 3.31% (12) | 12.00 | >2.00 | <0.001 |
| T139K | 0.00% (0) | - | - | 2.20% (8) | 13.14 | 6.62 | <0.001 |
| T139R | 0.00% (0) | - | - | 1.10% (4) | 6.57 | 2.33 | 0.008 |
| V179D | 1.43% (9) | 1.00 | 1.84 | 4.68% (17) | 3.76 | 9.45 | 0.002 |
| Y181C | 0.63% (4) | 0.18 | 0.02 | 10.47% (38) | 4.22 | 13.37 | <0.001 |
| M184V | 0.16% (1) | 1.00 | 0.31 | 20.39% (74) | 74.00 | 37.00 | <0.001 |
| Y188L | 0.00% (0) | - | - | 1.38% (5) | 1.25 | >2.00 | 0.003 |
| G190A | 0.00% (0) | - | - | 7.16% (26) | 11.07 | 24.78 | <0.001 |
| H221Y | 0.00% (0) | - | - | 6.61% (24) | 2.40 | 6.65 | <0.001 |
| L228R | 0.00% (0) | - | - | 1.65% (6) | 3.00 | 3.71 | 0.001 |
Note:
a
The reference strain is CRF_BC.CN.CN54. The mutations listed denote the reference amino acid from HIV-1 subtype CRF07_BC.
b
The bold mutations are those that have not been reported to be associated with drug resistance.
c
P-value was computed by using chi-square test.