Table 2. Mean values in RLS severity (IRLS), quality of life (SF-36), depression (CES-D) and sleep (PSQI) scales at baseline 12-months, 24-months and 36-months follow-up.
| Scale | Baseline (Q1) | 12-months F-up (Q3) | 24-months F-up (Q4) | 36-months F-up (Q5) | p-value a |
| RLS severity scale (IRLS), mean | 25.2 | 25.2 | 23.2 | 23.0 | <0.01 |
| Short-Form 36 Health Survey (SF-36), means | |||||
| Physical Functioning (PF) | 64.1 | 65.0 | 62.9 | 60,3 | <0.01 |
| Role Physical (RP) | 50.1 | 50.5 | 47.4 | 46.9 | <0.01 |
| Role Emotional (RE) | 67.7 | 68.4 | 67.1 | 66.2 | <0.01 |
| Social Functioning (SF) | 68.6 | 69.0 | 68.6 | 67.3 | <0.01 |
| Mental Health (MH) | 63.2 | 63.2 | 62.4 | 62.2 | <0.01 |
| Bodily Pain (BP) | 50.4 | 50.5 | 50.3 | 50.6 | 0.22 |
| Vitality (VT) | 46.6 | 47.1 | 47.2 | 45.8 | <0.01 |
| General Health (GH) | 49.9 | 49.7 | 50.9 | 50.1 | 0.05 |
| Physical Component Summary | 39.2 | 39.3 | 38.9 | 38.4 | <0.01 |
| Mental Component Summary | 46.1 | 46.2 | 46.2 | 45.8 | 0.24 |
| Center for Epidemiologic Studies Depression Scale (CES-D) | 17.9 | 17.7 | 17.8 | 18.1 | 0.07 |
| Depressive affect | 4.1 | 4.2 | 4.1 | 4.3 | 0.04 |
| Somatic symptoms | 6.5 | 6.5 | 6.6 | 6.7 | <0.01 |
| Positive affect | 6.6 | 6.5 | 6.5 | 6.6 | 0.23 |
| Interpersonal relations | 0.4 | 0.4 | 0.4 | 0.4 | 0.03 |
| Pittsburgh Sleep Quality Index (PSQI) | 10.3 | 10.4 | 10.6 | 10.7 | <0.01 |
a
p-value for difference between assessments according to one-way repeated measures ANOVA.