Table 1. Functional category of upregulated genes in Rh-BMDMs infected with Mtb-H or Mtb-A.
| Category | Mtb-H* | Mtb-A* |
| TNF | TNF (6.5), TNFAIP3 (10.2), TNFRSF14 (2.3), TNFRSF18 (2.8),TNFRSF10C (3.3), TNFRSF11A (2.5), TNFSF13B (2.2),TRAF2 (3.0), TRAF4 (5.5), TRAF6 (2.1), TRAF3IP2 (4.9), LTA (3.0) | |
| APOPOTOSIS | BID (9.5) CAPN3 (12.4) MAP2K7 (3.1), MAPK8 (3.9), NFKBIA (8.2), NRAS (10.2), TNF (6.5 | |
| INTERFERONS | IFIT1 (4.9) | GBP1 (2.2), GBP3 (9.7), IFI44 (2.7), IFIH1 (3.7), IFIT1 (15.5), IFIT2 (5.2), IFIT3 (4.3), IFIT1B (4.7) |
| CHEMOKINES | IRF1 (8.9) | CXCL10 (9.5), CXCR5 (3.6) |
| ACTIVATION OF NEUTROPHILS | F2 (7.8), TNF (6.5), EDN1 (6.3) | HMGB1 (2.4) |
| DNA DAMAGE | GADD45B (64.2),GADD45G (30.3), DDIT3 (10.95), DDIT4 (4.78) | GADD45A (0.433) |
| AUTOPHAGY | CFLAR (14.3), ERN1 (12.6), DDIT3 (11.3) BAG3 (7.2), TNF (6.5),CHEK1 (6.4), GAB1 (5.9), DDIT4 (5.0), MAPK8 (3.9), SIRT1 (3.3),TRAF2 (3.0) PPFIA4 (2.8), TICAM1 (2.7), BAIAP2 (2.6), PTGER2 (2.4),SOD1 (2.3), ATG13 (2.2) | |
| BINDING OF PHAGOCYTES | DLL1 (14.8), F2 (7.8), TNF (6.5), SELPLG (3.4), HMGB1 (2.4), TRAF6 (2.1), PTPN6 (2.0) | |
| CHEMOKINE | CAMK2D (2.5), FOS (7.2), MAPK8 (3.9), NRAS (10.2) | |
| IMMUNERESPONSE | TGFBR2 (3.0), IFNE (2.9), PRDM1 (2.9), PNP (2.9), TXNIP (2.8),TNFRSF18 (2.8), SPIB (2.7) GNA13 (2.7), TICAM1 (2.7),ZFP36 (2.6), DUSP10 (2.6), PTTG1 (2.6), EAF2 (2.6), TNFRSF11A (2.5),ATF2 (2.5), UPP1 (2.5), SCGB1A1 (2.5), HLA-DRB4 (2.5), HMGB1 (2.4),PTGER2 (2.4), EFNB1 (2.4), PRKG1 (2.3), SGK1 (2.3), TNFRSF14 (2.3),EGFR (2.3), IL1RL1 (2.3), NQO2 (2.3), SOD1 (2.3), ZBTB7B (2.3),TNFSF13B (2.2), HBEGF 2.2, TRAF6 (2.1), PTPN6 (2.0) | IFIT1 (15.5),CXCL10 (9.5),IFIT2 (5.2),SPIB (3.9), IFIH1 (3.7), CXCR5 (3.6), POU2F2 (3.4), ISG15 (3.2), RIPK4 (2.9),PLCL2 (2.7), IFI44 (2.7), KIT(2.7) BLNK (2.7), IDO1 (2.7), EDNRB (2.5), TPO (2.4), TPO(2.4), CAMP(2.4),EDN2 (2.3), VCAM1(2.2), IRAK3(2.2) |
| INFLAMMATION | NLRP3 (21.8), MAP3K8 (20.2), THBD (11.4), TNFAIP3 (10.2), BID (9.5), ATF3 (9.4), SPDEF (9.0), NFKBIA (8.2), F2 (7.8), RIPK4 (7.4), NR4A3 (7.1), TNF (6.5), DUSP1 (5.6), TRAF4 (5.5), SLC26A1 (5.0), TRAF3IP2 (4.9), ID3 (4.4), SLC7A9 (4.3), PTGER4 (4.0), MAPK8 (3.9), IL5 (3.8), ZC3H12A (3.7), NFKBIZ (3.7), EGR1 (3.6), TYMP (3.6), PPM1D (3.4), SIRT1 (3.3), SERPINC1 (3.2), LTA (3.0), TGFBR2 (3.0), TICAM1 (2.7), ZFP36 (2.6), PTTG1 (2.6), EAF2 (2.6), ATF2 (2.5), UPP1 (2.5), HMGB1 (2.4), PRKG1 (2.3), SGK1 (2.3), EGFR (2.3), IL1RL1 (2.3), NQO2 (2.3), SOD1 (2.3), TNFSF13B (2.2), TRAF6 (2.1) | CXCL10 (9.5), ISG15 (3.2), BLNK (2.7), IDO1 (2.7), EDNRB (2.5), CAMP (2.4), EDN2 (2.3), IRAK3 (2.2) |
| NFKB SIGNALLING | MAP3K8 (20.2), NRAS (10.2), TNFAIP3 (10.2), NFKBIA (8.2),BMP4 (6.7), TNF (6.5), PIK3C2A (4.0), MAPK8 (3.9), PIK3CB (3.6),MAP2K7 (3.1), LTA (3.0), ZAP70 (3.0), TRAF2 (3.0), TGFBR2 (3.0),TNFRSF11A (2.5), EGFR (2.3), TNFSF13B (2.2), TRAF6 (2.1) |
*Up-regulated genes in Rh-BMDMs infected with Mtb-H or Mtb-A by microarray. Fold change values are shown in bracket for each gene. To distinguish, alternate categories are shown in bold text.