Table 1. Clinicopathological variables of all patients (n = 332).

Clinicopathological variables	Number	%
Age at diagnosis
<50	86	25.9
≥50	246	74.1
pT stage
pT1	208	62.7
pT2	120	36.1
pT3	4	1.2
Histological grade
G I	76	22.9
G II	185	55.7
G III	71	21.4
Estrogen receptor status
Negative	79	23.8
Positive	253	76.2
Progesterone receptor status
Negative	103	31.0
Positive	229	69.0
HER-2 status
Negative	291	87.7
Positive	41	12.3
Ki-67 expression
Low	225	67.8
High	95	28.6
Missing	12	3.6
Intratumoral CD8+ CTLs positive infiltrate score
0	47	14.2
1+	143	43.1
2+	75	22.6
3+	67	20.2
Peritumoral CD8+ CTLs positive infiltrate score
0	16	4.8
1+	126	38.0
2+	117	35.2
3+	73	22.0
CD8+ CTLs infiltrate status
Negative	47	14.2
Positive	285	85.8
Death
Due to cancer	53	16.0
Unrelated to cancer	45	13.6
	41	12.3
Unknown causes	7	2.1
Surviving	227	68.4
Relapse
Yes	90	27.1
No	242	72.9

HER-2 human epidermal growth factor receptor 2; CTLs, cytotoxic T lymphocytes.

CD8⁺ CTLs infiltrate status was done based on dichotomising of intratumoral CD8⁺ CTLs positive infiltrate scores.