Table 1. Clinicopathologic characteristics and DACH1 methylation status of 104 patients with esophageal squamous cell carcimoma.

		Methylation status
Clinical parameter	No.	Methylated	Unmethylated	P value*
		n = 64 (61.5%)	n = 40 (38.5%)
Age (year)
<50	27	14 (51.9%)	13 (48.1%)	P = 0.2292
≥50	77	50 (64.9%)	27 (35.1%)
Gender
Male	82	47 (57.3%)	35 (42.7%)	P = 0.0876
Female	22	17 (77.3%)	5 (22.7%)
Differentiation
Poorly	45	34 (75.6%)	11 (24.4%)	P = 0.0103#
Moderately/Well	59	30 (50.9%)	29 (49.1%)
Tumor stage
I/II	71	39 (54.9%)	32 (45.1%)	P = 0.0422#
III/IV	33	25 (75.8%)	8 (24.2%)
Metastasis
Negative	69	39 (56.5%)	30 (43.5%)	P = 0.1398
Positive	35	25 (71.4%)	10 (28.6%)
Tumor size
≥5 cm	33	18 (54.6%)	15 (45.4%)	P = 0.3176
<5 cm	71	46 (64.8%)	25 (35.2%)

*P values are obtained from chi-square test.

^#Statistical significance is indicated by P<0.05.