Table 2. Top regions of copy number gains and losses in NASH.
Cytoband | Samplefrequency (%) | DGVcoverage (%) | Start | End | Size (kb) | Number of geneswithin demarcatedregion | Candidategene (s) |
Amplification | |||||||
14:q11.2 | 53.8 | 100 | 19,728,641 | 20,420,849 | 692.21 | 15 | OR |
5:p15.33 | 41 | 100 | 723,194 | 820,424 | 97.23 | 3 | – |
11:p15.4 | 35.9 | 100 | 5,893,184 | 5,935,144 | 41.96 | 3 | OR |
12:p13.31 | 33.3 | 100 | 9,637,323 | 9,718,846 | 81.52 | 0 | – |
Deletion | |||||||
11:q11 | 35.9 | 100 | 55,368,154 | 55,450,788 | 82.63 | 6 | OR |
14:q24.3 | 33.3 | 100 | 74,001,651 | 74,022,324 | 20.67 | 3 | ACOT1 |
16:q12.2 | 33.3 | 100 | 55,832,511 | 55,853,358 | 20.85 | 1 | CES1 |
4:q13.2 | 33.3 | 100 | 69,392,545 | 69,483,277 | 90.73 | 1 | – |
Amplification &Deletion | |||||||
12:p13.2 | 38.5 | 100 | 11,219,788 | 11,249,210 | 29.42 | 4 | TASR |
Start = first base-pair location in the copy number region, End = last base-pair location in the copy number region.