Skip to main content
. 2014 Apr 17;10(4):e1004069. doi: 10.1371/journal.ppat.1004069

Figure 4. The dominant p11C-specific cells exhibited decreased antigen-specific expansion compared to subdominant epitope-specific cells.

Figure 4

PBMCs from monkeys chronically-infected with either SIVmac251 (A) or SIVsmE660 (B) were stimulated in vitro with either p11C (red), p54E660/AS (blue), or p68A (green) peptide, harvested on days 3, 4, 5, 6, 8, 10, 12, and 14 following stimulation, and measured by flow cytometry to calculate the percent of tetramer-positive CD8+ T cells. Expansion was calculated as the fold change of the percent of each tetramer-positive population on each day, relative to day 0. Data from three SIVmac251- and three SIVsmE660-infected monkeys are shown. Measurements were conducted between weeks 40–52 for SIVmac251 and 31–44 for SIVsmE660.