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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Lab Chip. 2013 Feb 21;13(4):602–609. doi: 10.1039/c2lc90148j

Figure 1.

Figure 1

(a) Schematic of a microfluidic device using magnets placed under a main flow channel, along with magnetically-labeled CTCs, to accomplish CTC isolation from a blood sample. (b) Microfluidic device with magnets placed under perpendicularly-oriented side chambers used for collection of magnetically-labeled CTCs; the low fluid shear stresses in the dead-ended side chambers keep the collected CTCs viable. (c) Microfluidic device with a flow-focusing configuration to establish a single-file stream of cells through a microfluidic channel. Device is bonded to a micro-Hall detector array, such that each magnetically-labeled CTC passing over the array induces a Hall voltage and is thus counted. Reproduced from Refs. 8, 9, 10 with permission from RSC and AAAS.