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Effects of ESR1 disruption on postnatal growth and serum gonadotropin and sex steroid hormone levels. Adult wild-type and Esr1-null males (10 weeks of age) and adult wild-type and Esr1-null females (8 weeks of age) were weighed (A) and crown-rump length (B) and serum levels of LH (C), FSH (D), testosterone (E), and 17β-estradiol (F) measured. Sample size was ≥10 per genotype. Asterisks indicate a significant difference between the genotypes: *, P < .001; **, P < .002; ***, P < .02.
