Table 2.

Changes of Calcium Oscillations in GnRH Neurons in Response to ADP or AICAR

Dose	Peaks/min	Peaks/min	Inhibition (Whole Population, %)	GnRH Responders (%)	Inhibition (GnRH Responders, %)	n	N
	SFM	ADP
0.1 μg/mL	1.3 ± 0.08	1.15 ± 0.08a	12 ± 6	12	18 ± 8	85	3
0.5 μg/mL	1.58 ± 0.05	1.26 ± 0.06b	20 ± 3	22	51 ± 5	157	4
2 μg/mL	1.76 ± 0.07	1.32 ± 0.06b	25 ± 4	29	48 ± 5	226	6
5 μg/mL	1.31 ± 0.1	0.8 ± 0.07b	38 ± 6	25	55 ± 9	60	2
		AICAR
0.2 mM	1.29 ± 0.06	1.31 ± 0.07 (NS)	0	8	50 ± 8	74	2
0.5 mM	1.45 ± 0.06	1.06 ± 0.06b	26 ± 4	26	58 ± 7	128	4
1 mM	0.98 ± 0.05	0.77 ± 0.05b	22 ± 5	12	63 ± 8	116	4

t test: NS, P = .410.

^aP = .0008.

^bP < .0001.