Figure 2.

The GH/IGF-I axis is markedly altered in male and female LiGHRKO mice compared with controls. A–H, Serum was collected at 6 months of age and used to determine levels of GH, IGF-I, and IGFBPs in male and female LiGHRKO (black bars; n = 9–16/group per sex) and control (white bars; n = 10–16/group per sex) mice. Levels of circulating (A) GH, (B) IGF-I, (C) IGFBP-1, (D) IGFBP-2, (E) IGFBP-3, (F) IGFBP-5, (G) IGFBP-6, and (H) IGFBP-7 are shown. All values are represented as mean ± SEM. P values that were considered significant (P < .05) are indicated; LiGHRKO (FFCx) vs control (FFxx).