Table 3.
First author | Average follow-up period | Follow-up completeness (%) | Group | No. of patients (n) | Patient survival (n) | Graft survival (n) | Acute rejection (n) | Chronic rejection (n) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 year | 2 year | 3 year | 5 year | 1 year | 2 year | 3 year | 5 year | |||||||
Comparison of Tac-based regimen with steroid or not (Sect. I) | ||||||||||||||
Langrehr [25] | 425 days | 100 | Tac + steroid | 15 | 14 | 14 | 7 | |||||||
Tac + MMF | 15 | 14 | 14 | 4 | ||||||||||
Pelletier [26] | 412 days | 100 | Tac + MMF + steroid | 36 | 32 | 32 | 5 | |||||||
Tac + MMF | 36 | 30 | 29 | 9 | ||||||||||
Margarit al. [27] | 100 | Tac + steroid | 32 | 27 | 25 | 23 | 24 | 19 | 19 | 10 | 0 | |||
Tac | 28 | 24 | 23 | 18 | 24 | 23 | 18 | 11 | 0 | |||||
Reggiani al. [17] | 31 months | 100 | Tac + MMF + steroid | 18 | 18 | 15 | 3 | |||||||
Tac + MMF | 12 | 11 | 11 | 9 | ||||||||||
Junge [28] | 67 months | 100 | Tac + steroid | 14 | 13 | 6 | 1 | |||||||
Tac + MMF | 16 | 16 | 6 | 0 | ||||||||||
Chen [9] | 100 | Tac + MMF + steroid | 26 | 12 | 3 | |||||||||
Tac + MMF | 28 | 18 | 4 | |||||||||||
Vivarelli [29] | 841 days | 100 | Tac + steroid | 16 | 12 | 4 | ||||||||
Tac | 23 | 18 | 2 | |||||||||||
Manousou [30] | 53.5 months | 100 | Azathioprine + steroid + Tac | 49 | 43 | 31 | ||||||||
Tac | 54 | 45 | 22 | |||||||||||
Weiler [31] | 100 | Tac + steroid | 54 | 48 | 46 | 44 | 43 | 44 | 43 | 42 | 39 | 14 | 0 | |
Tac | 56 | 48 | 44 | 43 | 39 | 47 | 41 | 40 | 36 | 19 | 16 | |||
Comparison of Tac-based regimen with induction agents or not (Sect. II) | ||||||||||||||
Eason [32] | 18.5 months | 100 | Tac + MMF + steroid | 59 | 50 | 49 | 47 | 18 | ||||||
RATG + Tac + MMF | 60 | 51 | 49 | 49 | 15 | |||||||||
Boillot [33] | 100 | Tac + steroid | 347 | 92 | ||||||||||
Daclizumab + Tac | 351 | 89 | ||||||||||||
Spada [34] | 100 | Tac + steroid | 36 | 33 | 33 | 31 | 31 | 11 | ||||||
Basiliximab + Tac | 36 | 32 | 32 | 29 | 29 | 4 | ||||||||
Humar [35] | 24 months | 100 | Tac + MMF + steroid | 83 | 67 | 67 | 10 | |||||||
Basiliximab + Tac + MMF | 83 | 73 | 71 | 9 | ||||||||||
Kato [36] | 100 | Tac/MMF + steroid | 39 | 31 | 31 | 17 | ||||||||
Daclizumab + Tac/MMF | 31 | 23 | 21 | 10 | ||||||||||
Gras [37] | 100 | Tac + steroid | 34 | 31 | 30 | |||||||||
Basiliximab + Tac | 50 | 48 | 47 | |||||||||||
Foroncewicz [18] | 6 years | 100 | Tac + steroid | 18 | 4 | |||||||||
Daclizumab + Tac | 7 | 1 | ||||||||||||
Klintmalm [38] | 20.9 months | 100 | Tac + MMF + steroid | 72 | 58 | 57 | 7 | |||||||
Daclizumab + Tac + MMF | 146 | 126 | 124 | 17 |
MMF mycophenolate mofetil, RATG rabbit antithymocyte globulin, Tac tacrolimus