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. 2014 Mar 20;8(2):198–215. doi: 10.1007/s12072-014-9523-y

Table 3.

Summary of primary endpoints including survival rates and rejection rates in this study

First author Average follow-up period Follow-up completeness (%) Group No. of patients (n) Patient survival (n) Graft survival (n) Acute rejection (n) Chronic rejection (n)
1 year 2 year 3 year 5 year 1 year 2 year 3 year 5 year
Comparison of Tac-based regimen with steroid or not (Sect. I)
 Langrehr [25] 425 days 100 Tac + steroid 15 14 14 7
Tac + MMF 15 14 14 4
 Pelletier [26] 412 days 100 Tac + MMF + steroid 36 32 32 5
Tac + MMF 36 30 29 9
 Margarit al. [27] 100 Tac + steroid 32 27 25 23 24 19 19 10 0
Tac 28 24 23 18 24 23 18 11 0
 Reggiani al. [17] 31 months 100 Tac + MMF + steroid 18 18 15 3
Tac + MMF 12 11 11 9
 Junge [28] 67 months 100 Tac + steroid 14 13 6 1
Tac + MMF 16 16 6 0
 Chen [9] 100 Tac + MMF + steroid 26 12 3
Tac + MMF 28 18 4
 Vivarelli [29] 841 days 100 Tac + steroid 16 12 4
Tac 23 18 2
 Manousou [30] 53.5 months 100 Azathioprine + steroid + Tac 49 43 31
Tac 54 45 22
 Weiler [31] 100 Tac + steroid 54 48 46 44 43 44 43 42 39 14 0
Tac 56 48 44 43 39 47 41 40 36 19 16
Comparison of Tac-based regimen with induction agents or not (Sect. II)
 Eason [32] 18.5 months 100 Tac + MMF + steroid 59 50 49 47 18
RATG + Tac + MMF 60 51 49 49 15
 Boillot [33] 100 Tac + steroid 347 92
Daclizumab + Tac 351 89
 Spada [34] 100 Tac + steroid 36 33 33 31 31 11
Basiliximab + Tac 36 32 32 29 29 4
 Humar [35] 24 months 100 Tac + MMF + steroid 83 67 67 10
Basiliximab + Tac + MMF 83 73 71 9
 Kato [36] 100 Tac/MMF + steroid 39 31 31 17
Daclizumab + Tac/MMF 31 23 21 10
 Gras [37] 100 Tac + steroid 34 31 30
Basiliximab + Tac 50 48 47
 Foroncewicz [18] 6 years 100 Tac + steroid 18 4
Daclizumab + Tac 7 1
 Klintmalm [38] 20.9 months 100 Tac + MMF + steroid 72 58 57 7
Daclizumab + Tac + MMF 146 126 124 17

MMF mycophenolate mofetil, RATG rabbit antithymocyte globulin, Tac tacrolimus