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Inhibition of P-gp transport in immortalized human hCMEC/D3 cells derived from the blood-brain barrier. IC50 values ± SEM for inhibition of P-gp transport of R123 (○) (0.5 μg/mL) and calcein-AM (□) (0.5 μM) by QT (A and B) and QT2C2Me2 (8) (C and D) in immortalized human hCMEC/D3 cells. Each curve represents the mean of three independent experiments ± SEM. The original flow cytometry data from which these results were derived are shown in Figure S3.
