Table 3. Binding Parameters for Quenching of P-gp Trp Fluorescence by Binding of QT and QT Dimersa.
compd | ΔFmax (%) | Kd (μM) |
---|---|---|
QT | 65 ± 2.7 | 29 ± 2.9 |
QT2C2 (1) | 45 ± 0.8 | 1.5 ± 0.1 |
QT2C2Me2 (8) | 43 ± 0.9 | 1.0 ± 0.1 |
Kd values were estimated by fitting of the quenching data from 3 independent experiments, and represents the mean ± fitting error.