Table.
Global Burden Analyses of ROHs
| Entire Data Set | |||
|
AD Cases (n = 547) |
Controls (n = 542) |
P Value | |
| No. of ROHs | 8225 | 8912 | |
| Rate, ROHs per person | 15.04 | 16.44 | .99 |
| Total distance spanned by ROHs per person, kb | 36 200 | 34 300 | .23 |
| Mean ROH size per person, kb | 2133 | 1934 | .0039 |
| Familial AD Subgroup | |||
|
AD Cases (n = 267) |
Controls (n = 542) |
P Value | |
| No. of ROHs | 4041 | 8912 | |
| Rate, ROHs per person | 15.13 | 16.44 | .94 |
| Total distance spanned by ROHs per person, kb | 39 600 | 34 300 | .05 |
| Mean ROH size per person, kb | 2260 | 1934 | .0005 |
| African Hispanic Subgroup | |||
|
AD Cases (n = 207) |
Controls (n = 192) |
P Value | |
| No. of ROHs | 1858 | 1700 | |
| Rate, ROHs per person | 8.98 | 8.85 | .39 |
| Total distance spanned by ROHs per person, kb | 21 180 | 17 640 | .07 |
| Mean ROH size per person, kb | 2014 | 1875 | .12 |
| European Hispanic Subgroup | |||
|
AD Cases (n = 329) |
Controls (n = 326) |
P Value | |
| No. of ROHs | 5949 | 5966 | |
| Rate, ROHs per person | 18.08 | 18.30 | .65 |
| Total distance spanned by ROHs per person, kb | 44 550 | 40 190 | .11 |
| Mean ROH size per person, kb | 2221 | 1994 | .013 |
Abbreviations: AD, Alzheimer disease; kb, kilobase; ROHs, runs of homozygosity.