Table 3.
Treatment-Related Toxicity
| Toxicity Type | Treatment Arm A (n=135) Grade |
||||
|---|---|---|---|---|---|
| 1 (%) | 2 (%) | 3 (%) | 4 (%) | 5 (%) | |
| Hemoglobin | 27 | 4 | - | - | - |
| Fatigue | 30 | 25 | 10 | 1 | - |
| Weight loss | 19 | 7 | 1 | - | - |
| Dry skin | 27 | 12 | 2 | - | - |
| Alopecia | 18 | 2 | - | - | - |
| Pruritus/itching | 27 | 13 | 1 | - | - |
| Rash/desquamation | 3 | 5 | 1 | - | - |
| Rash: acne/acneiform | 28 | 39 | 9 | - | - |
| Erythema multiforme | - | 1 | - | - | - |
| Hand-foot reaction | 1 | 2 | 1 | - | - |
| Diarrhea w/o prior colostomy | 38 | 20 | 10 | - | - |
| Dry mouth | 16 | 1 | - | - | - |
| Dysphagia | 1 | 1 | - | - | - |
| Muco-stomatitis (symptom) oral cavity | 16 | 7 | 1 | - | - |
| Nausea | 25 | 11 | 4 | - | - |
| Vomiting | 14 | 3 | 3 | - | - |
| Alkaline phosphatase | 9 | 2 | - | - | - |
| ALT, SGPT | 9 | 2 | 1 | 1 | - |
| AST, SGOT | 8 | 2 | 2 | - | - |
| Bilirubin | 12 | 9 | - | - | - |
| Hyperglycemia | 19 | 3 | 1 | - | - |
| Hyponatremia | 12 | - | 2 | - | - |
| Dry eye syndrome | 7 | 1 | 1 | - | - |
| Pneumonitis/pulmonary infiltrates | - | - | 1 | - | 1 |