Figure 5. Dynamic regulation of gene expression changes in hSOD1G93A mice.
Levels of mRNA in G93A spinal cords are represented as percentages of wildtype controls of the same time points. (A) GluR1 mRNA in G93A spinal cords showed a significant decrease at 18 week. (B) GluR2 mRNA increased at 6 weeks and decreased at 18 weeks. (C) CB1 mRNA increased significantly at 9 week, while decreased at 12, 15 and 18 week. N = 10 spinal cord preparations in each group. Unpaired t test. * p<0.05; ** p<0.01, ***p<0.001. Error bars represent SEM.