Figure 6.

Total cholesterol, LDL-C and HDL-C levels after injection of a neutralizing monoclonal antibody against PCSK9 compared to a control antibody against keyhole limpet hemocyanin (KLH). Results are expressed as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001 vs. anti-KLH control antibody at the same time point, n = 4 per group. (from Chan J. et al. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9820–5).