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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Immunol Rev. 2014 Jan;257(1):127–144. doi: 10.1111/imr.12139

Fig. 3. Elements of synthetic chimeric antigen receptors.

Fig. 3

Schematic of ligand binding, non-signaling, and signaling elements of a CAR that can be altered to optimize tumor cell recognition and signaling of T-cell function.