Fig. 3.

Showing how subcortical volumes change with age and puberty stage in (A) females and (B) males using the best-fit combined or interactive model for each structure.

Age is presented on the x-axis, whilst puberty stage is indicated by the coloured lines (Red — Tanner stage 1, Yellow — Tanner stage 2, Green — Tanner stage 3, Blue — Tanner stage 4, Purple — Tanner stage 5). Data for each graph were extracted from the combined models by calculating Intercept + (coefficient for main effect of Tanner x Tanner stage) + (coefficient for main effect of Age-centred x Age-centred) + (coefficient for interactive effect of Tanner-by-age x Tanner stage x Age). Age ranges for each Tanner stage line were decided using the ages and pubertal variation in our sample (see Fig. 1 for range). The age-only model for each structure is included (black dotted line) to aid interpretation.

*For the caudate in males, there is no significant model that explains the developmental trajectory.