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A cartoon schematic of two pathways for RNA cleavage by RNase E and the degradosome: 5′ end sensing and the 5′ bypass pathway. A). Activation of RNase E by 5′ end sensing to trigger domain closure. B). Proposed model for how the CTD might affect 5′ end bypass by capturing and presenting potential substrates to the catalytic domain. The red bars represent the two RNA binding domains in the C-terminal half of RNase E.
