Table I. Comparison of recent series of fetoscopic tracheal occlusion. The randomized controlled trial (RCT) by Harrison et al. had very wide selection criteria (Harrison et al., 2003). Only 3 patients met the criteria of the FETO task group (Jani et al., 2009), of whom two were treated in utero.
| Harrison et al. (2003)N = 11 |
FETO consortium (2009) N = 210 |
|
|---|---|---|
| Criteria for surgery (left) | LHR < 1.4 and liver “up” | LHR < 1.0 and liver “up” |
| Anaesthesia | General | Loco-regional or local |
| Access through abdominal wall | Laparotomy | Percutaneous |
| Access diameter | 5 mm cannula | 3.3 mm cannula |
| Occlusive device | Clip or balloon | balloon |
| Operation time | N.R. | 10 (3-93) min |
| Reversal of occlusion | – | Deflation rate: 17/209 (8%) |
| EXIT delivery | In utero reversal | |
| PPROM < 34 weeks | 100% | 25% |
| PPROM < 37 weeks | 100% | 47% |
| Mean gestational age at birth | 30.8 (28-34) | 35.3 wks (25.7-41.0) |
| Survival till discharge (LHR < 1.4) | 73% (8/11) (controls: 77%) | Not eligible |
| Survival till discharge (LHR < 1.0) | 1/3 (33%) | 86/175 (49%) |
| Survival till discharge for Right CDH | – | 12/34 (35%) |