Fig. 2. a,b) Facial appearance in trisomy 18:micrognathia, low set ears, hirsutism; c) the hands in trisomy 18 with camptodactyly, the index overlapping the third finger and the fifth digit overlapping the fourth (courtesy by Rudi Bagusat); d) trisomy 18 with clenched hands, clubfeet and omphalocoele.