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. 2014 Apr;33(4):429–437. doi: 10.1016/j.healun.2013.11.004

Figure 1.

Figure 1

Efficient expression of FoxP3 in TGF-β–induced Tregs enhances BM engrafment in a murine mixed chimerism model. (A) Representative FACS blot depicting FoxP3 expression among CD4 T cells after in vitro cultivation in the presence of TGF-β. (B) Schematic drawing of the non-cytotoxic BMT protocol using Tregs. Recipient-type CD4 T cells were separated by magnetic bead sorting and cultivated in the presence of TGF-β in vitro. Tregs were infused with fully mismatched allogeneic donor BM under the cover of costimulation blockade and rapamycin.