Table 3.

Scope of cross-coupling reaction of arylmagnesium bromides.

Entry	Product			Ni(dppe)CI2 [mol %]	Yield [%][a]	S.M. ee [%][b]	Prod ee [%][b]	es [%]
1		17	R = H	2	67	>99	91	92
2		18	R = NMe2	5	80	>99	nd[c]	nd[c]
3		19	R = OMe	2	86[d]	>99	97	97
4		20	R = F	2	82[d]	>99	87	88
5		21		10	76	>99	93	94
6		22		5	80	>99	85	86
7			23	4	92[d]	96	88	92
8			24	10	71	97	95	98
9[e]			25	20	76	99	93	94

^[a]Isolated yield after silica gel chromatography.

^[b]Determined by chiral SFC.

^[c]nd = not determined; enantiomers are inseparable by chiral SFC chromatography.

^[d]Calculated yield; see SI for details.

^[e]Ni(dppe)CI₂ was added in two aliquots of 10 mol %; see SI for details.