Table 1.
Comparison of inter-day and intra-day imprecision and accuracy for plasma (over 21 days), DBS (manual), CSF and automated DBS extraction (all over three days).
| Imprecision [RSD%] | Accuracy [% of Nominal] | ||||||
|---|---|---|---|---|---|---|---|
| Plasma | DBS | CSF | Plasma | DBS | CSF | ||
|
|
|||||||
| Concentration | |||||||
| Intra-day: | |||||||
| 198 ng/ml | 4.8 | 6.7 | 8.3 | 93.5 | 102.0 | 110.0 | |
| 593 ng/ml | 2.7 | 4.5 | 9.2 | 104.0 | 99.0 | 104.0 | |
| 16000 ng/ml | 3.4 | 4.0 | 4.0 | 106.0 | 105.0 | 89.5 | |
| Inter-day: | 198 ng/ml | 8.7 | 8.3 | 11.7 | 99.1 | 103.0 | 102.0 |
| 593 ng/ml | 3.4 | 6.3 | 10.9 | 107.0 | 104.0 | 100.0 | |
| 16000 ng/ml | 6.3 | 8.5 | 6.3 | 102.0 | 105.0 | 93.0 | |
| Automated Extraction | |||||||
| Intra-day: | 198 ng/ml | 17.8 | 94.9 | ||||
| 593 ng/ml | 5.8 | 96.5 | |||||
| 16000 ng/ml | 5.4 | 95.9 | |||||
| Inter-day: | 198 ng/ml | 8.1 | 96.4 | ||||
| 593 ng/ml | 15.3 | 90.2 | |||||
| 16000 ng/ml | 15.9 | 96.7 | |||||