Table 2.
Blood-to-plasma distribution of acetaminophen in human EDTA blood samples Ten EDTA whole blood samples were collected from different individuals. These samples were spiked with 198 ng/ml, 593 ng/ml and 16,000 ng/ml (n=10/each concentration). After spiking, plasma was prepared, the acetaminophen concentration in plasma was quantified as described and compared to the nominal concentration spiked into the whole blood sample. Abbreviation: SD: standard deviation.
| Nominal Concentration in blood [ng/ml] | Plasma [ng/ml] | Concentration blood [%] | Nominal Concentration in blood [ng/ml] | Plasma [ng/ml] | Concentration blood [%] | Nominal Concentration in blood [ng/ml] | Plasma [ng/ml] | Concentration blood [%] |
|---|---|---|---|---|---|---|---|---|
| 198 | 174 | 87.9 | 593 | 413 | 69.6 | 16000 | 11400 | 71.3 |
| 198 | 152 | 76.8 | 593 | 408 | 68.8 | 16000 | 10900 | 68.1 |
| 198 | 140 | 70.7 | 593 | 463 | 78.1 | 16000 | 11500 | 71.9 |
| 198 | 138 | 69.7 | 593 | 510 | 86.0 | 16000 | 9860 | 61.6 |
| 198 | 156 | 78.8 | 593 | 439 | 74.0 | 16000 | 9260 | 57.9 |
| 198 | 131 | 66.2 | 593 | 409 | 69.0 | 16000 | 9810 | 61.3 |
| 198 | 166 | 83.8 | 593 | 453 | 76.4 | 16000 | 10200 | 63.8 |
| 198 | 133 | 67.2 | 593 | 425 | 71.7 | 16000 | 10100 | 63.1 |
| 198 | 117 | 59.1 | 593 | 384 | 64.8 | 16000 | 9280 | 58.0 |
| 198 | 146 | 73.7 | 593 | 426 | 71.8 | 16000 | 10100 | 63.1 |
|
| ||||||||
| Mean | 145.3 | 73.4 | mean | 433.0 | 73.0 | mean | 10241 | 64.0 |
| SD | 17.2 | 8.7 | SD | 35.6 | 6.0 | SD | 790.3 | 4.9 |