(A, B)
In vivo activity pattern of hs1431 (at e11.5) and hs746 (at
e13.5). OPT data is represented in red (LacZ, enhancer active) and green (no
LacZ, enhancer inactive). (C, D) Expression levels of enhancer
target genes in craniofacial tissues dissected from wild-type (gray) and
knockout (red) littermate embryos. Error bars show the variation among
individuals of the same genotype (SEM). *, P < 0.05 (Student T-test,
1-tailed); Mble, mandibular; Mx, maxillary; MNP, medial nasal process; LNP,
lateral nasal process.