Table V.

Comparison of NO and ET-1 levels in the two groups, prior to and following treatment.

Group	ET-1, ng/l	NO, μmol/l
Metformin (n=47)
Prior to treatment	81.3±12.8	35.6±8.3
Following treatment	37.5±7.4	60.3±11.2
P-value	0.008	0.009
Pioglitazone (n=46)
Prior to treatment	82.2±12.6	34.7±9.0
Following treatment	57.6±9.4	50.1±10.4
P-value	0.030	0.042

Values are expressed as mean ± SD. ET-1, endothelin; NO, nitric oxide.