Table I.
Clinical data of patients with severe sepsis.
| Item | Survival group (n=34) | Mortality group (n=24) | Total (n=58) | P-value |
|---|---|---|---|---|
| Male, n (%) | 26 (76.4) | 17 (70.8) | 43 (74.1) | 0.629 |
| Age, years | 69.2±17.5 | 74.6±10.8 | 71.5±15.2 | 0.157 |
| No comorbidity | 4 (11.8) | 0 | 4 (6.9) | 0.082 |
| Comorbidity, n (%) | ||||
| Cerebral infarction | 12 (35.3) | 9 (37.5) | 21 (36.2) | 0.863 |
| COPD | 11 (32.4) | 3 (12.5) | 14 (24.1) | 0.082 |
| CHD | 6 (17.6) | 8 (33.3) | 14 (24.1) | 0.169 |
| HTN | 4 (11.8) | 5 (20.8) | 9 (15.5) | 0.347 |
| ACEI/ARB | 3 (8.8) | 2 (8.3) | 5 (8.6) | 0.948 |
| Diabetes mellitus | 4 (11.8) | 3 (12.5) | 7 (12.1) | 0.933 |
| Pneumoconiosis | 0 | 3 (12.5) | 3 (5.2) | 0.034 |
| APACHE II | 19.8±6.3 | 25.5±6.0 | 22.2±6.7 | 0.001 |
| SOFA | 5.1±2.2 | 7.3±1.7 | 6.1±2.3 | <0.001 |
| Source of infection, n (%) | ||||
| Pneumonia | 27 (79.4) | 22 (91.7) | 49 (84.5) | 0.204 |
| Urosepsis | 4 (11.8) | 0 | 4 (6.9) | 0.082 |
| Biliary infection | 1 (2.9) | 2 (8.3) | 3 (5.2) | 0.361 |
| Soft tissue infection | 2 (5.8) | 0 | 2 (3.4) | 0.227 |
| Multiple foci | 3 (8.8) | 2 (8.3) | 5 (8.6) | 0.948 |
| Treated type, n (%) | ||||
| Elective surgery | 1 (2.9) | 0 | 1 (1.7) | 0.397 |
| Emergency surgery | 5 (14.7) | 2 (8.3) | 7 (12.1) | 0.463 |
| Medical | 28 (82.4) | 22 (91.7) | 50 (86.2) | 0.311 |
| Cause of ICU admission, n (%) | ||||
| Respiratory failure | 29 (85.3) | 21 (87.5) | 50 (86.2) | 0.810 |
| Shock | 14 (41.2) | 20 (83.3) | 34 (58.6) | 0.001 |
| Treatment in ICU, n (%) | ||||
| Mechanical ventilation | 25 (73.5) | 24 (100) | 49 (84.5) | 0.032 |
| Vasopressor agents | 14 (41.2) | 20 (83.3) | 34 (58.6) | 0.001 |
| Use of glucocorticoids | 12 (35.3) | 18 (75) | 30 (51.7) | 0.003 |
| Complication, n (%) | ||||
| Shock | 14 (41.2) | 20 (83.3) | 34 (58.6) | 0.001 |
| AKI | 11 (32.4) | 17 (70.8) | 28 (48.3) | 0.004 |
| ALI/ARDS | 12 (35.3) | 18 (75) | 30 (51.7) | 0.003 |
COPD, chronic obstructive pulmonary disease; CHD, coronary heart disease; HTN, hypertension; ACEI, angiotensin-converting enzyme inhibitors; ARB, angiotensin receptor antagonist; APACHE II, Acute Physiology and Chronic Health Evaluation II; SOFA, Sepsis-related Organ Failure Assessment; ICU, intensive care unit; AKI, acute kidney injury; ALI/ARDS, acute lung injury/acute respiratory distress syndrome.