Figure 6.

Effects of LY294002 and Akt inhibitor IV on α-SMA and type I collagen. (A and B) Quantitative PCR demonstrated that the mRNA expression levels of α-SMA and type I collagen were higher in the OVA-induced mice compared with the control, and LY294002 and Akt inhibitor IV significantly decreased their expression. (C) The same result may be observed in the protein expression levels as shown by western blot analysis. ^*P<0.05, vs. control. α-SMA, α smooth muscle actin; OVA, ovalbumin; PCR, polymerase chain reaction; Akt, protein kinase B.