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DSP-4 administration resulted in a long-term NE depletion. HPLC analysis of monamines showed reduced NE levels in DSP-4 treated mice regardless of genotype, with 50% reductions in the frontal cortex and cerebellum and a 75% loss in the hippocampus. DSP-4 did not alter levels of other monoamines, such as serotonin (5-HT), dopamine, or their metabolites (data not shown).
