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. Author manuscript; available in PMC: 2014 Apr 18.
Published in final edited form as: J Alzheimers Dis. 2011;23(3):471–489. doi: 10.3233/JAD-2010-101218

Fig. 7.

Fig. 7

Cal 28k was affected by DSP-4 administration in Ts65Dn mice. A–C) Cal 28k immunostaining of NS Sal (A), Ts65Dn Sal (B), and Ts65Dn DSP-4 (C) showed that the distribution of Cal 28k was altered in the CA1 region of Ts65Dn DSP-mice, with greater loss in pyramidal neurons (arrowhead) than in interneurons of stratum oriens (arrow). D) Densitometry confirmed decreased Cal 28k-IR in the Ts65Dn DSP-4 group (mean ± SEM, *p < 0.05 relative to NS Sal). E) Hippocampal gene expression of BDNF mRNA was reduced in the Ts65Dn saline and DSP-4 groups compared to NS groups (mean ± SEM; *p < 0.05).