Table 2. Description of 64 shared-types (SITs; n = 394 isolates) and corresponding spoligotyping defined lineages/sublineages starting from a total of 414 M. tuberculosis strains isolated from Colombian patients.
SIT* | Spoligotype Description | Octal Code | Nb in study | % in this study | % in study vs. Database | Lineage** | Clustered vs. Unique patterns*** |
2 | □□□□□□□□□□□□□□□□□□□□□□□□▪□□□□□□▪□□□□▪▪▪▪▪▪▪ | 000000004020771 | 2 | 0.48 | 0.51 | H2 | Clustered |
3 | □□□□□□□□□□□□□□□□□□□□□□□□▪▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪ | 000000007720771 | 1 | 0.24 | 0.95 | H3 | Unique |
4 | □□□□□□□□□□□□□□□□□□□□□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 000000007760771 | 1 | 0.24 | 0.28 | Unknown | Unique |
8 | ▪□□□□□□□□□□□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪□▪▪▪▪▪▪▪▪▪ | 400037777413771 | 1 | 0.24 | 0.55 | EAI5 | Unique |
17 | ▪▪□▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 677737607760771 | 2 | 0.48 | 0.3 | LAM2 | Clustered |
20 | ▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 677777607760771 | 7 | 1.69 | 0.86 | LAM1 | Clustered |
33 | ▪▪▪▪▪▪▪▪□□□▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 776177607760771 | 3 | 0.72 | 0.27 | LAM3 | Clustered |
37 | ▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777737777760771 | 2 | 0.48 | 0.43 | T3 | Clustered |
42 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777777607760771 | 124 | 29.95 | 3.78 | LAM9 | Clustered |
45 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□□□□▪□□□□▪▪▪▪▪▪▪ | 777777764020771 | 6 | 1.45 | 5.66 | H1 | Clustered |
47 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪□□□□▪▪▪▪▪▪▪ | 777777774020771 | 2 | 0.48 | 0.13 | H1 | Clustered |
50 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪ | 777777777720771 | 34 | 8.21 | 1.02 | H3 | Clustered |
53 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777777777760771 | 21 | 5.07 | 0.34 | T1 | Clustered |
62 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪□□□□▪▪▪□▪▪▪ | 777777774020731 | 97 | 23.43 | 17.7 | H1 | Clustered |
64 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪□▪▪▪□□□□▪▪▪▪▪▪▪ | 777777607560771 | 1 | 0.24 | 0.27 | LAM6 | Unique |
86 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777777737760771 | 1 | 0.24 | 1.09 | T1 | Unique |
91 | ▪▪▪□□□□□□□□□□▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 700036777760771 | 5 | 1.21 | 1.98 | X3 | Clustered |
93 | ▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777737607760771 | 1 | 0.24 | 0.28 | LAM5 | Unique |
102 | ▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777703777760771 | 1 | 0.24 | 1.37 | T | Unique |
106 | ▪▪▪▪▪▪▪▪□□□▪▪▪▪▪▪▪▪□□□□□□□□□□□□□□□□□□□▪▪▪▪▪ | 776177400000171 | 1 | 0.24 | 0.76 | Unknown | Unique |
124 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪▪▪▪▪▪▪ | 777777777700771 | 2 | 0.48 | 3.03 | Unknown | Clustered |
130 | ▪▪▪▪▪▪▪▪□□□▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪□▪▪▪ | 776177607760731 | 1 | 0.24 | 0.93 | LAM3 | Unique |
162 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪□▪▪▪▪ | 777777607760671 | 1 | 0.24 | 3.23 | LAM9 | Unique |
167 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪▪□□□□▪▪▪▪▪▪▪ | 777777777660771 | 1 | 0.24 | 1.37 | T1 | Unique |
207 | ▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪ | 767777777720771 | 8 | 1.93 | 25.81 | H3 | Clustered |
230 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777777603760771 | 1 | 0.24 | 5.56 | LAM9 | Unique |
237 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□□□□□□□□ | 777777777700000 | 1 | 0.24 | 0.93 | Unknown | Unique |
254 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777760007760771 | 1 | 0.24 | 0.57 | T5-RUS1 | Unique |
316 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□□▪□□□□▪▪▪□▪▪▪ | 777777770020731 | 1 | 0.24 | 2.13 | H3 | Unique |
379 | ▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪□□□□□▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777741017760771 | 2 | 0.48 | 9.52 | Unknown | Clustered |
384 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪□□□□□□▪□□□□▪▪▪▪▪▪▪ | 777777674020771 | 1 | 0.24 | 11.11 | H1 | Unique |
447 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777760377760771 | 1 | 0.24 | 12.5 | T1 | Unique |
727 | ▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪□□□□▪▪▪□▪▪▪ | 777737774020731 | 13 | 3.14 | 34.21 | H1 | Clustered |
753 | ▪□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 477777607760771 | 1 | 0.24 | 5 | LAM1 | Unique |
881 | ▪▪▪▪▪▪▪▪□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□□□□□□□▪▪▪□▪▪▪ | 776377770000731 | 6 | 1.45 | 24 | Unknown | Clustered |
1243 | ▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪ | 777377777720771 | 1 | 0.24 | 6.25 | H3 | Unique |
1277 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777777207760771 | 1 | 0.24 | 3.85 | LAM9 | Unique |
1283 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪□□□□▪▪▪▪▪▪▪ | 777777777020771 | 1 | 0.24 | 11.11 | H3 | Unique |
1486 | □▪▪□□□□□□□□□□▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 300036777760771 | 1 | 0.24 | 33.33 | X3 | Unique |
1533 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪ | 777763777720771 | 2 | 0.48 | 28.57 | H3 | Clustered |
1536 | ▪▪▪▪▪▪▪▪□□▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 776377607760771 | 1 | 0.24 | 4.76 | LAM9 | Unique |
1561 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪□□□□□▪▪▪▪▪▪ | 777777774020371 | 1 | 0.24 | 20 | H1 | Unique |
1804 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪ | 777777577720771 | 2 | 0.48 | 28.57 | H3 | Clustered |
1832 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777773607760771 | 1 | 0.24 | 5 | LAM9 | Unique |
2025 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□□▪▪▪▪▪▪ | 777777777700371 | 1 | 0.24 | 9.09 | T | Unique |
2114 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777761777760771 | 1 | 0.24 | 14.29 | T1 | Unique |
2497 | ▪▪□▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 677677607760771 | 1 | 0.24 | 16.67 | LAM1 | Unique |
2865 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪□□▪▪□□□□▪▪▪▪▪▪▪ | 777777607460771 | 1 | 0.24 | 25 | LAM9 | Unique |
2940 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪□□▪▪▪▪ | 777777607760471 | 2 | 0.48 | 28.57 | LAM9 | Clustered |
3010 | ▪▪▪▪▪▪▪▪□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪□▪▪▪ | 776377777740731 | 3 | 0.72 | 33.33 | S | Clustered |
3018* | ▪▪▪▪▪▪▪□□□□□□□□▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 774006777760771 | 1 | 0.24 | 50 | X1 | Unique |
3019* | ▪□▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 577737607760771 | 1 | 0.24 | 25 | LAM5 | Unique |
3020* | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪□▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777777607360771 | 1 | 0.24 | 25 | LAM9 | Unique |
3022* | ▪▪▪□□□□□□□□□▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪□□□□▪▪▪□▪▪▪ | 700077774020731 | 3 | 0.72 | 100 | H1 | Clustered |
3023* | ▪▪▪□□▪▪▪□□□▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 716177607760771 | 1 | 0.24 | 50 | LAM3 | Unique |
3039* | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□▪□▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777761377760771 | 3 | 0.72 | 75 | T4 | Clustered |
3040* | ▪▪▪▪▪▪▪▪▪□▪▪▪▪□▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪□▪▪▪▪ | 777367607760671 | 1 | 0.24 | 50 | LAM9 | Unique |
3041* | ▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪□□□□ | 677777607760700 | 2 | 0.48 | 66.67 | LAM | Clustered |
3042* | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪□□□□□□▪□□□□▪▪▪□▪▪▪ | 777777674020731 | 1 | 0.24 | 50 | H1 | Unique |
3043* | ▪▪▪▪□□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪□□□□▪▪▪▪▪▪▪ | 743777774020771 | 1 | 0.24 | 50 | H1 | Unique |
3044* | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪□□□□□□□□□▪▪▪▪ | 777777607700071 | 2 | 0.48 | 100 | Unknown | Clustered |
3045* | ▪▪□▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪□□□□□□□□□□□□□□□□□□□□□□□ | 677737600000000 | 1 | 0.24 | 50 | Unknown | Unique |
3311* | □□□□□□▪▪□□□▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 006177607760771 | 1 | 0.24 | 33.33 | LAM3 | Unique |
3462* | ▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777740377760771 | 1 | 0.24 | 50 | T1 | Unique |
* newly created SITs due to 2 or more strains belonging to an identical new pattern within this study or after a match with an orphan in the database; SIT designations followed by number of strains: 3018* this study n = 1, USA n = 1; 3019* this study n = 1, BRA n = 2, SEN n = 1; 3020* this study n = 1, FXX n = 1, GNB n = 2; 3022* this study n = 3; 3023* this study n = 1, CUB n = 1; 3039* this study n = 3, COL n = 1; 3040* this study n = 1, ESP n = 1; 3041* this study n = 2, BRA n = 1; 3042* this study n = 1, VEN n = 1; 3043* this study n = 1, DEU n = 1; 3044* this study n = 2; 3045* this study n = 1, VEN n = 1; 3311* this study n = 1,COL n = 2; 3462* this study n = 1, FXX n = 1;
** Lineage designations according to SITVIT2 using revised SpolDB4 rules; “Unknown” designates patterns with signatures that do not belong to any of the major lineages described in the database.
*** Clustered strains correspond to a similar spoligotype pattern shared by 2 or more strains “within this study”; as opposed to unique strains harboring a spoligotype pattern that does not match with another strain from this study. Unique strains matching a preexisting pattern in the SITVIT2 database are classified as SITs, whereas in case of no match, they are designated as “orphan” (see Table 1).