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. 2014 Apr 18;9(4):e95130. doi: 10.1371/journal.pone.0095130

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© 2014 Prashad, Charlton

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, Timeline of the low frequency stimulation experiment. B, Timeline of the high frequency stimulation experiment. In A and B, the black arrows () mark the time when test stimuli (Phasic – three single pulses at 0.1 Hz; tonic – three, 200 Hz, 15- pulse trains at 0.1 Hz) were applied following injection, and below each timeline is a diagram depicting the stimulation protocol for phasic and tonic recordings (in B, an example of the high frequency stimulation (HFS) protocol is given from time elapsed mark of 120 min to 180 min). Baseline recording (BR): Phasic – three single pulses at 0.1 Hz every 10 min; tonic – three, 200 Hz, 15-pulse trains at 0.1 Hz every 10 min. High frequency stimulation (HFS): Phasic – burst stimuli of 10 Hz for 2 min with an inter-burst interval of 2 min; tonic – burst stimuli of 150 Hz for 30 sec with an inter-burst interval of 10 sec. INJ – injection, RP – rest period.

Inline graphic — A, Timeline of the low frequency stimulation experiment. B, Timeline of the high frequency stimulation experiment. In A and B, the black arrows () mark the time when test stimuli (Phasic – three single pulses at 0.1 Hz; tonic – three, 200 Hz, 15- pulse trains at 0.1 Hz) were applied following injection, and below each timeline is a diagram depicting the stimulation protocol for phasic and tonic recordings (in B, an example of the high frequency stimulation (HFS) protocol is given from time elapsed mark of 120 min to 180 min). Baseline recording (BR): Phasic – three single pulses at 0.1 Hz every 10 min; tonic – three, 200 Hz, 15-pulse trains at 0.1 Hz every 10 min. High frequency stimulation (HFS): Phasic – burst stimuli of 10 Hz for 2 min with an inter-burst interval of 2 min; tonic – burst stimuli of 150 Hz for 30 sec with an inter-burst interval of 10 sec. INJ – injection, RP – rest period.