Table 4. The results of ROI specific ACM/FA disease score correlations and GLM analyses.

Region of interest	Pearson's correlation		GLM with correction for age and gender		r2
	ACM	FA	ACM	FA	ACM	FA
R-superior longitudinal fasciculus	−0.46(b*)	NS	0.57(b*)	0.51(b*)	0.33	0.26
R-corticospinal tract	−0.29(*)	NS	0.50(b*)	0.50(b*)	0.25	0.25
R-Posterior corona radiate	−0.62(b*)	NS	0.70(b*)	0.53(b*)	0.49	0.28
L-Posterior corona radiate	NS	NS	0.52(b*)	0.53(*)	0.27	0.28

Legend: The first column lists of a WM region of interest delineated in the JHU-ICBM-DTI-81 atlas with the letters R and L indicating a specific hemisphere. The second and third columns show Pearson's correlations between the summary statistics of median ACM or median FA and the EDSS disease scores. Boneferroni correction is used to account for multiple ROI comparisons (n = 10) and the (b*) indicates a Boneferroni corrected significant correlation at a significance level of 0.05 and (*) indicates uncorrected significance (0.05 level) while NS means not significant. The fourth and fifth column gives the linear estimate of disease score prediction based on a general linear model (GLM) including covariates of age, gender and either the median ACM or median FA while r² is the coefficient of determination, summarizing the percentage of variance explained by the model.