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. Author manuscript; available in PMC: 2014 Apr 18.
Published in final edited form as: Expert Opin Ther Targets. 2013 Nov 4;18(1):95–107. doi: 10.1517/14728222.2014.851671

Figure 2. Potential strategies to improve the responsiveness of HSPCs to S1P by targeting the S1P–S1P receptor axis.

Figure 2

S1P-mediated homing of HSPCs to BM could be improved by upregulating the S1P level in the BM microenvironment by DOP or THI, which inhibit SPL activity by blockade of the S1P2 receptor on transplanted donor cells (e.g., employing JTE-013) or by inhibiting the LPP and SPP receptors on donor HSPCs (e.g., with XY-14). Similar strategies could be helpful in directing other types of stem cells involved in the regeneration of damaged tissues (e.g., MSCs, EPCs, and VSELs).