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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2013 Dec 23;5(3):301–305. doi: 10.1002/wrna.1212

Figure 3.

Figure 3

Translational regulation by tRNA modification. tRNA contains many modified nucleobases. Anti-codon modification influences decoding processes and the overall translation capacity. Oxidative stress has multiple effects on tRNA metabolism, including m5C at the wobble position, tRNA misacylation, and tRNA cleavage. In addition, metabolic homeostasis such as sulfur amino acid levels regulates tRNA thiolation at the wobble position. These tRNA modifications trigger translational reprogramming in response to stress conditions.