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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Feb 6;34(5):996–1001. doi: 10.1161/ATVBAHA.113.303113

Figure 1. Kaplan-Meier survival curves following CLP.

Figure 1

Severe sepsis induced by CLP generated varying mortalities observed over a 5 day period. All wild-types succumbed to septic burden prior to the 72 hour mark. Deletion of the gene encoding VWF (VWF KO) significantly alleviated septic burden as the rate of mortality was reduced with several mice surviving past 5 days (p = 0.003). Conversely, ablation of a functional platelet GP Ib-IX axis (hIL-4R/Ibα) resulted in no discernible differences in survival when compared to wild-type (p = 0.614). N = 8 for each group. P values were determined by a Logrank analysis.