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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2013 Dec 16;5(3):335–346. doi: 10.1002/wrna.1214

Figure 1. Molecular mechanisms for reducing oxidized RNA in cells.

Figure 1

RNA may become non-functional once is oxidized. At the early stage after oxidation modification, the RNA may possibly be reverted to normal, functional RNA by repair activities. Oxidized RNA is also subjected to degradation, which is responsible to irreversibly eliminate probably the majority of oxidized RNA. The oxidized nucleotides resulted from degradation are blocked from transcription, reducing the formation of oxidized RNA by synthesis. RNA molecules are shown as blue lines. Oxidized residues in RNA are marked by a red “X”.