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DLD-based separation by cell shape and deformability.12 (A) DLD separation based on effective cell diameter. (B) Different forms of RBCs in normal and abnormal states. (C) Shear-induced deformation of RBCs affects effective cell diameter. (D) Orientation affects effective cell diameter. (E, F, G) Channel depth affects RBC orientation, hence effective cell diameter and cell trajectory in a DLD device.
