Fig. 1.

Management of a chronic diabetic ulcer on the knee area using adipose stem cell-based therapy and a collagen sponge. (A) Chronic open wound on the knee area with exposure of the patella bone (before treatment). (B) Adequate size of artificial dermis (Terudermis®) is submerged in cell suspension. (C) Debridement of wound and application of ASC-seeded artificial dermis is placed on the defect and sutured to the adjacent wound margin. (D) Vascular tissue ingrowth is noted after 2 weeks. (E) After removal of the silicone layer of the artificial dermis, a thin split thickness skin graft is placed on the engineered vascular bed. (F) Two weeks after skin graft placement.