Table 1.
Patient characteristics
| DESH | non-DESH | p value | |
|---|---|---|---|
| Gender (male/female) |
4/6 |
6/6 |
|
| Age (years) |
75.7 ± 4.4 |
77 ± 9.3 |
0.17 |
| Tap positive |
8 |
5 |
|
| Shunt operation |
7 |
3 |
|
| Shunt success |
6 |
2 |
|
| AChE inhibitor prescription |
3 |
5 |
|
| Opening CSF pressure (cmH2O) |
14.8 ± 1.7 |
14.8 ± 1.3 |
0.99 |
| Evans index (%) |
34.5 ± 2.8 |
32.7 ± 4.3 |
0.27 |
| Callosal angle (degrees) |
79.9 ± 5.5 |
101.2 ± 4.3 |
0.01* |
| ARWMC |
9.2 ± 1.6 |
13.3 ± 2.0 |
0.19 |
| MMSE |
22.5 ± 4.6 |
18.1 ± 6.4 |
0.05 |
| FAB |
11.4 ± 4.0 |
9.9 ± 4.0 |
0.27 |
| TUG (s) |
17.8 ± 0.8 |
29.8 ± 5.7 |
0.04* |
| TUG (step) |
24.2 ± 0.6 |
38 ± 5.0 |
0.01* |
| iNPHGS |
7.3 ± 0.9 |
9.1 ± 1.0 |
0.24 |
| t-tau (pg/mL) |
319.9 ± 31 |
546.2 ± 54 |
0.003* |
| Aβ42 (pM) |
59.2 ± 7.5 |
57.2 ± 6.0 |
0.84 |
| Aβ40 (pM) |
1198 ± 76 |
1314 ± 45 |
0.19 |
| L-PGDS (μg/mL) | 14.4 ± 1.0 | 20.8 ± 2.0 | 0.01* |
Data are numbers or the mean ± the standard deviation. iNPH: idiopathic normal pressure hydrocephalus, DESH, disproportionately enlarged subarachnoid-space hydrocephalus, AChE: acetylcholinesterase, ARWMC: age related white matter change, MMSE: mini-mental state examination, FAB: frontal assessment battery, TUG: timed up and go test, iNPHGS: iNPH grading scale, t-tau: total tau, Aβ: amyloid beta, L-PGDS: lipocalin-type prostaglandin D synthase. *: p < 0.05.